Book DescriptionThis title summarises and reviews the important field of genetic therapy with respect to the latest immunological advances in the lab and clinic. It offers a unique treatment of immunology and immunotherapy in gene - approached from a vector and target organ point of view rather than from the perspective specific diseases. It presents a broad appeal - applicable for immunology and genetics/gene therapy, recombinant DNA studies, transplantation, virology, cancer research and tumor research.
Table of Contents 1. The immunology of gene transfer: an overview 2. Innate immune responses to nucleic acids 3. The antiviral Innate immune response 4. Immune responses to adenoviral vectors 5. Immune responses to lentiviral vectors 6. Immune responses to adeno-associated virus vectors 7. Immunology after in utero and neonatal gene transfer 8. Immunology of hepatic gene transfer 9. Immune responses to adenoviral, AAV, and lentiviral vector used for gene therapy of brain diseases 10. Immunology of cutaneous gene transfer 11. Immune responses to pulmonary gene therapy 12. Induction of immune tolerance through gene transfer to hematopoietic stem cells 13. Reconstitution of the immune system by gene therapy 14. Genetics of the Immune Response to Proteins Expressed After Gene Transfer 15. Immune modulation and transient suppression strategies 16. Gene therapy for autoimmune diseases 17. Engineering of viral capsids to evade the host immune system