Book Description
Medicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations.
• Adopts a novel biosynthetic theme rather than a traditional descriptive approach
• Includes extensive further reading at the end of the chapter
• Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal
products
• Includes the latest developments in the field
• New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids
• User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations
Booknews
This comprehensive guide to pharmacognosy, the scientific study of natural health remedies from herbs, animal products, and inorganic materials, is directed primarily toward undergraduate students— whether or not such material is integrated with traditional pharmacy courses. Dewick (pharmaceutical sciences, U. of Nottingham, UK) provides a foundation in natural product chemistry/phytochemistry and nomenclature before proceeding to coverage of the primary and secondary metabolism of the reactions of these diverse substances; and the pathways involved in the biosynthesis of several classes of popular natural medicines represented by echinacea, kava, feverfew, taxol, alkaloids, garlic, and various vitamins. The chapters include molecular structure diagrams, boxed material, and further reading. Annotation c. Book News, Inc., Portland, OR (booknews.com)
A text for an undergraduate pharmacy course reflecting the recent tendency to teach about pharmaceuticals derived from plants, antibiotics from microbials, and steroidal and prostanoid drugs from animals as a single subject. Pivots on the notion of biosynthesis as the metabolic sequence leading to various selected classes of natural products. Applies fundamental chemical principles and shows the relationships between the various structures encountered in nature to provide a rationale for natural products. Seeks more to engender an understanding of the structures and how living organisms put them together than to transfer a mass of descriptive information. The material is ample and diverse enough to be selected from to tailor a specific course. References are not only chapter-specific, but classified into the several compounds discussed. Annotation c. by Book News, Inc., Portland, Or.
Table of Contents
1 About this Book, and How to Use it
2 Secondary Metabolism: The Building Blocks and Construction Mechanisms
Primary and Secondary Metabolism
The Building Blocks
The Construction Mechanisms
Some Vitamins Associated with the Construction Mechanisms
3 The Acetate Pathway: Fatty Acids and Polyketides
Saturated Fatty Acids
Unsaturated Fatty Acids
Acetylenic Fatty Acids
Branched-Chain Fatty Acids
Prostaglandins
Thromboxanes
Leukotrienes
Aromatic Polyketides
Macrolides and Polyethers
Cyclization Through Diels-Alder Reactions
Genetic Manipulation of the Acetate Pathway
4 The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids
Aromatic Amino Acids and Simple Benzoic Acids
Cinnamic Acids
Lignans and Lignin
Phenylpropenes
Benzoic Acids from C[subscript 6]C[subscript 3] Compounds
Coumarins
Styrylpyrones
Flavonoids and Stillbenes
Flavonolignans
Isoflavonoids
Terpenoid Quinones
5 The Mevalonate and Deoxyxylulose Phosphate Pathways: Terpenoids and Steroids
Hemiterpenes (C[subscript 5])
Monoterpenes (C[subscript 10])
Irregular Monoterpenes
Iridoids (C[subscript 10])
Sesquiterpenes (C[subscript 15])
Diterpenes (C[subscript 20])
Sesterterpenes (C[subscript 25])
Triterpenes (C[subscript 30])
Tetraterpenes (C[subscript 40])
Higher Terpenoids
Steroids
6 Alkaloids
Alkaloids Derived from Ornithine
Alkaloids Derived from Lysine
Alkaloids Derived from Nicotinic Acid
Alkaloids Derived from Tyrosine
Alkaloids Derived from Tryptophan
Alkaloids Derived from Anthranilic Acid
Alkaloids Derived from Histidine
Alkaloids Derived by Amination Reactions
Purine Alkaloids
7 Peptides, Proteins, and Other Amino Acid Derivatives
Peptides and Proteins
Ribosomal Peptide Biosynthesis
Peptide Hormones
Nonribosomal Peptide Biosynthesis
Peptide Antibiotics
Peptide Toxins
Modified Peptides: Penicillins, Cephalosporins, and Other [beta]-Lactams
Cyanogenic Glycosides
Glucosinolates
Cysteine Sulphoxides
8 Carbohydrates
Monosaccharides
Oligosaccharides
Polysaccharides
Aminosugars
Aminoglycosides
Index