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Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics (IE, 8th)
소비자가격 120,000원 0%할인
판매가격 120,000원 1,200점 적립
출판사 McGrawHill
저자 Murray P.Ducharne Leon Shargel
발행일 2022
판형 19.4×24.0×4.6
페이지 수 1010
ISBN 9781260469608
제품코드 9781260469608
주문수량
상세설명 상품후기(0) 상품문의(0) 교환 및 반품/배송/결제

Description:

 

 The authoritative textbook on the principles and practical applications of biopharmaceutics and pharmacokinetics

 

Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics has been the standard textbook in its field for over 40 years.  This eighth edition includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas.  Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development.

 

Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition has been expanded and revised to include advancements in biopharmaceutics and pharmacokinetics. The chapter sequence has been reorganized into four main sections, providing a more logical sequence for students. The textbook starts with fundamental concepts, followed by application of these principles to optimize drug therapy and to the rational development of drug products. Each chapter includes theoretical concepts with practical examples and clinical applications. Frequently asked questions provide a discussion of overall concepts.

 

Features:

⚫ Expanded and revised chapters to include scientific advances in biopharmaceutics and pharmacokinetics

Four main sections providing a natural buildup of knowledge: introduction to biopharmaceutics and

pharmacokinetics, fundamentals of biopharmaceutics, pharmacokinetic calculations, clinical pharmacokinetics  

and pharmacodynamics, and biopharmaceutics and pharmacokinetics in drug product development 

⚫ Additional chapters for this edition include:   

o Physiological factors related to drug absorption

o Approaches to pharmacokinetics and pharmacodynamics calculations 

o Novel and complex dosage Forms

o Clinical Development and Therapeutic Equivalence of Generic Drug and Biosimilar Products

o Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development 

⚫ Additional information on drug therapy, drug product performance, and other related topics
⚫ Frequently asked questions, practice problems, clinical examples and learning questions

 

- Table of Contents -


PART I

Introduction to Biopharmaceutics and Pharmacokinetics


Chapter 1. Introduction to Biopharmaceutics and Pharmacokinetics

Chapter 2. Mathematical Fundamentals in Pharmacokinetics

Chapter 3. Biostatistics


PART II

Fundamentals of Biopharmaceutics


Chapter 4. Physiologic Factors Related to Drug Absorption

Chapter 5. Drug Distribution and Protein Binding

Chapter 6. Physiology of Drug Elimination

Chapter 7. Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance

Chapter 8. Drug Product Performance, In Vivo : Bioavailability and Bioequivalence

Chapter 9. Modified-Release Drug Products and Drug Devices

Chapter 10. Targeted Drug Delivery Systems and Biotechnoloy Products


PART III

Pharmacokinetic Principles


Chapter 11. Introduction to Pharmacokinetic and Pharmacodynamic Models and Analyses

Chapter 12. One-Compartment Open Model: Intravenous Bolus Administration

Chapter 13. Multicompartment Models: Intravenous Bolus Administraion

Chapter 14. Intravenous Infusion 

Chapter 15. Pharmacokinetic Calculations for Drug Elimination and Clearance

Chapter 16. Pharmacokinetics of Drug Absorption

Chapter 17. Multiple-Dosage Regimens

Chapter 18. Nonlinear Pharmacokinetics

Chapter 19. Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental PK/PD Analyses

Chapter 20. Applications of Software Packages in Pharmacokinetics


PART IV

Pharmacodynamics and Clinical Pharmacokinetics


Chapter 21. Pharmacogenetics, Drug Metabolism, Transporters, and Individualization

Chapter 22. Relationship between Pharmacokinetics and Pharmacodynamics

Chapter 23. Application of Pharmacokinetics to Clinical Situations

Chapter 24. Applicarion of Pharmacokinetics and Pharmacodynamics to Aging, Obese, and Pediatric Patients

Chapter 25. Dose Adjustment in Renal and Hepatic Diseases


PART V

Biopharmaceutics and Pharmacokinetics in Drug Product Development


Chapter 26. Biopharmaceutical Aspects of the Active Pharmaceutical Ingredient and Pharmaceutical Equivalence

Chapter 27. Rational Drug Development, Quality, and Performance

Chapter 28. FDA-Approved Novel Dosage Forms

Chapter 29. Clinical Development and Therapeutic Equivalence of Generic Drugs and Biosimilar Products 

Chapter 30. Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development

 

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