Book Description

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.
There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions:
• a comprehensive treatment of plant, microbial, and animal natural products in one volume
• extensive use of chemical schemes with annotated mechanistic explanations
• cross-referencing to emphasize links and similarities
• boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action
Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

Table of Contents

1 About this Book, and How to Use it
2 Secondary Metabolism: The Building Blocks and Construction Mechanisms
   Primary and Secondary Metabolism
   The Building Blocks
   The Construction Mechanisms
   Some Vitamins Associated with the Construction Mechanisms
3 The Acetate Pathway: Fatty Acids and Polyketides
   Saturated Fatty Acids
   Unsaturated Fatty Acids
   Acetylenic Fatty Acids
   Branched-Chain Fatty Acids
   Prostaglandins
   Thromboxanes
   Leukotrienes
   Aromatic Polyketides
   Macrolides and Polyethers
   Cyclization Through Diels-Alder Reactions
   Genetic Manipulation of the Acetate Pathway
4 The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids
   Aromatic Amino Acids and Simple Benzoic Acids
   Cinnamic Acids
   Lignans and Lignin
   Phenylpropenes
   Benzoic Acids from C[subscript 6]C[subscript 3] Compounds
   Coumarins
   Styrylpyrones
   Flavonoids and Stillbenes
   Flavonolignans
   Isoflavonoids
   Terpenoid Quinones
5 The Mevalonate and Deoxyxylulose Phosphate Pathways: Terpenoids and Steroids
   Hemiterpenes (C[subscript 5])
   Monoterpenes (C[subscript 10])
   Irregular Monoterpenes
   Iridoids (C[subscript 10])
   Sesquiterpenes (C[subscript 15])
   Diterpenes (C[subscript 20])
   Sesterterpenes (C[subscript 25])
   Triterpenes (C[subscript 30])
   Tetraterpenes (C[subscript 40])
   Higher Terpenoids
   Steroids
6 Alkaloids
   Alkaloids Derived from Ornithine
   Alkaloids Derived from Lysine
   Alkaloids Derived from Nicotinic Acid
   Alkaloids Derived from Tyrosine
   Alkaloids Derived from Tryptophan
   Alkaloids Derived from Anthranilic Acid
   Alkaloids Derived from Histidine
   Alkaloids Derived by Amination Reactions
   Purine Alkaloids
7 Peptides, Proteins, and Other Amino Acid Derivatives
   Peptides and Proteins
   Ribosomal Peptide Biosynthesis
   Peptide Hormones
   Nonribosomal Peptide Biosynthesis
   Peptide Antibiotics
   Peptide Toxins
   Modified Peptides: Penicillins, Cephalosporins, and Other [beta]-Lactams
   Cyanogenic Glycosides
   Glucosinolates
   Cysteine Sulphoxides
8 Carbohydrates
   Monosaccharides
   Oligosaccharides
   Polysaccharides
   Aminosugars
   Aminoglycosides
   Index