Book Descriptione
landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics―now fully updated.
- Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them
- Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency
- Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy
The field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts.
Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination. The book also helps you work with pharmacokinetic and biopharmaceutic parameters to design and evaluate dosage regimens of drugs. In the seventh edition of this must-have interactive learning tool, most of the chapters are updated to reflect our current understanding of complex issues associated with safe and efficacious drug therapy.

Table of Contents
1. Introduction to Biopharmaceutics and Pharmacokinetics
2. Mathematical Fundamentals in Pharmacokinetics
3. Biostatistics
4. One-Compartment Open Model: Intravenous Bolus Administration
5. Multicompartment Models: Intravenous Bolus Administraion
6. Intravenous Infusion
7. Drug Elimmination, Clearance, and Renal Clearance
8. Pharmacokinetics of Oral Absorption
9. Multiple-Dosage Regimens
10. Nonlinear Pharmacokinetics
11. Physiologic Drug Distribution and Protein Binding
12. Drug Elimination and Hepatic Clearance
13. Pharmacokinetics and Drug Metabolism
14. Physiology Factors Related to Drug Absorption
15. Biopharmaceutics Considerations in Drug Product Design and In Vitro Drug Product Performance
16. Drug Product Performance, In Vivo: Bioavaliability and Bioequivalence
17. Biopharmaceutical Aspects of the Active Pharmaceutical Ingredient and Pharmaceutical Equicalence
18. Impact of Biopharmaceutics on Drug Product Quality and Clincal Efficacy
19. Modified-Release Drug Products and Drug Devices
20. Targeted Drug Delivevy Systems and Biotechnological Products
21. Relationship Between Pharmacokinetics and Pharmacodynamics
22. Application of Pharmacokinetics to Clinical Situations
23. Applicarion of Pharmacokinetics to specific Populations: Gericatric, Obese, and Pediatric Patients
24. Dose Adjustment in Renal and Hepatic Disease
25. Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental Analtsis