From the PublisherSubstantially expanded in its second edition, Cancer Biology incorporates the important recent advances in research on the cellular and molecular biology of cancer and provides a comprehensive discussion of the mechanisms of carcinogenesis. The text describes the malignant transformation of cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of diseased cells into the host organism. In addition to a new chapter on the biology of tumor metastasis, there are three new chapters on cancer causation, dealing with the chemical and physical carcinogens; viruses and oncogenes; and chromosomal abnormalities and gene depression. Updated material on growth factors and their receptors, differentiation, and the cell matrix is also presented, and the pathophysiology of cancer as a clinical disease is discussed.
Table of Contents1 Characteristics of human cancer2 The epidemiology of human cancer3 Genetic alterations in cancer cells4 Phenotypic characteristics of cancer cells5 Alterations of cellular differentiation in cancer6 Causes of cancer7 Oncogenes8 Tumor suppressor genes9 Growth factors and signal transduction mechanisms10 Cell-cycle regulation and apoptosis11 Biology of tumor metastasis12 Host-tumor interactions: Tumor effects on the host13 Tumor immunology: Immunologic approaches to the diagnosis and treatment of cancer14 Gene-targeted therapy for cancer15 Cancer preventionIndex